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. 2022 Apr 13;14(4):278. doi: 10.3390/toxins14040278
AEME anhydroecgonine methyl ester
ATP adenosine triphosphate
BBB blood brain barrier
BE benzoylecgonine
CE cocaethylene
CNS central nervous system
CUD cocaine use disorder
CYP450 cytochrome P450
DAT dopamine transporter
DSM-5 Diagnostics and Statistics Manual of Mental Disorders 5th edition
EC ecgonine
ED ecgonidine
EDEE ecgonidine ethyl ester
EEE ecgonine ethyl ester
EMCDDA European Monitoring Centre for Drug and Drug Addiction
EME ecgonine methyl ester
FADM flavin adenine dinucleotide-containing monooxygenase
GC-MS gas chromatography coupled with mass spectrometry
GPx glutathione peroxidase
GSH reduced glutathione
hCE1 human carboxylesterase type 1
hCE2 human carboxylesterase type 2
HPLC high performance liquid chromatography
LC-MS/MS liquid chromatography coupled with tandem mass spectrometry
NAT noradrenaline transporter
NBE norbenzoylecgonine
NCE norcocaethylene
NCOC norcocaine
NCOC-NO orcocaine nitroxide
NCOC-NO+ norcocaine nitrosonium
NEDME norecgonidine methyl ester
NEME norecgonine methyl ester
NMDA N-methyl-D-aspartate
N-OH-NCOC N-hydroxy-norcocaine
(p-/m-)OH-BE (para-/meta-)hydroxybenzoylecgonine
(p-/m-)OH-COC (para-/meta-)hydroxycocaine
PChE pseudocholinesterase
ROS reactive oxygen species
SERT serotonin transporter
SOD superoxide dismutase
UPLC-MS/MS ultra-performance liquid chromatography coupled with tandem mass spectrometry