Table 2. Patient characteristics in the HAIC and standard chemotherapy cohorts.
| All (n = 34) | HAIC cohort (n = 10) | Standard chemotherapy cohort (n = 24) | P | ||
|---|---|---|---|---|---|
| Age | 64 (31–79) | 63 (36–78) | 64 (31–79) | 0.897 | |
| Sex | Male | 16 (47.1) | 5 (50) | 11 (45.8) | 0.824 |
| Female | 18 (52.9) | 5 (50) | 13 (54.2) | ||
| Smoking | Yes | 17 (50) | 3 (30) | 14 (58.3) | 0.132 |
| No | 17 (50) | 7 (70) | 10 (41.7) | ||
| Alcohol consumption | Yes | 15 (44.1) | 2 (20) | 13 (54.2) | 0.068 |
| No | 19 (55.9) | 8 (80) | 11 (45.8) | ||
| HBS antigen | Yes | 1 (2.9) | 0 (0) | 1 (4.2) | 0.512 |
| No | 33 (97.1) | 10 (100) | 23(95.8) | ||
| HCV | Yes | 4 (11.8) | 1 (10) | 3 (12.5) | 0.837 |
| No | 30 (88.2) | 9 (90) | 21 (87.5) | ||
| Diabetes mellitus | Yes | 7 (20.6) | 0 (0) | 7 (29.2) | 0.055 |
| No | 27 (79.4) | 10 (100) | 17 (70.8) | ||
| Obesity (BMI>25 kg/m2) | Yes | 7(20.6) | 2 (20) | 5 (20.8) | 0.956 |
| No | 27 (79.4) | 8 (80) | 19 (79.2) | ||
| Primary sclerosing cholangitis | Yes | 1 (2.9) | 1 (10) | 0 (0) | 0.116 |
| No | 33 (97.1) | 9 (90) | 24 (100) | ||
| Tumor number | Unifocal | 8 (23.5) | 2 (20) | 6(25) | 0.754 |
| Multifocal | 26 (76.5) | 8(80) | 18 (75) | ||
| Maximum diameter (mm) | 57.7 (10–121.77) | 47.5 (10–90) | 57.7 (15.79–121.77) | 0.515 | |
| CEA (ng/mL) | 5 (0.9–1969.4) | 5.05 (1–342) | 4.75 (0.9–1969.4) | 0.838 | |
| CA19-9 (mAU/mL) | 125.04 (2–96093.06) | 71.9 (2.2–1952) | 173.2 (2–969093.06) | 0.401 | |
| Distant metastasis (without liver) | Yes | 23 (67.6) | 6 (60) | 17 (70.8) | 0.538 |
| No | 11 (32.4) | 4 (40) | 7 (29.2) | ||
| Metastatic organ | Liver | 20 (58.8) | 6 (60) | 14 (58.3) | |
| Lung | 8 (23.5) | 1 (10) | 7 (29.2) | ||
| Lymph node | 15 (44.1) | 7 (70) | 8 (33.3) | ||
| peritoneum | 9 (26.5) | 0 (0) | 9 (37.5) | ||
| Bone | 3 (8.8) | 1 (10) | 2 (5.9) | ||
Data are expressed as median (range) or n (%)
CEA: carcinoembryonic antigen, CA19-9: carbohydrate antigen 19–9, HAIC: hepatic arterial infusion chemotherapy, HBS: hepatitis B antigen, HCV: hepatitis C virus.