Table 3. Adverse effects of hepatic arterial infusion chemotherapy using gemcitabine, cisplatin, and 5-fluorouracil vs systemic gemcitabine-cisplatin combination therapy.

Adverse effects	HAIC-GEM-FP (n = 18)		GC (n = 24)
	Any grade	Grade 3 or 4	Any grade	Grade 3 or 4	P
Leukopenia	2 (11.1)	1 (5.6)	11 (45.8)	3 (12.5)	0.049
Anemia	12 (66.7)	6 (33.3)	19 (79.2)	6 (25)	0.396
Thrombocytopenia	5 (27.8)	4 (22.2)	11 (45.8)	6 (25)	0.368
Hyperbilirubinemia	4 (22.2)	1 (5.6)	2 (8.3)	2 (8.3)	0.114
AST/ALT level elevation	4 (22.2)	0 (0)	4 (16.7)	0 (0)	0.650
Fever	4 (22.2)	0 (0)	3 (12.5)	0 (0)	0.403
General fatigue	3 (16.6)	0 (0)	2 (8.3)	0 (0)	0.409
Nausea/vomiting	1 (5.6)	0 (0)	2 (8.3)	0 (0)	0.729
Gastric ulcer	1 (5.6)	0 (0)	0 (0)	0 (0)	0.243
Artery occlusion	1 (5.6)	–	0 (0)	-	0.243

Data are expressed as n (%)

AST, alanine aminotransferase; ALT, aspartate transaminase; GC, gemcitabine plus cisplatin combination therapy