Table 4.
Quality of life (EORTC QLQ-C30) of patients operated on for MEN1-ZES and other dpNEN at last follow-up.
| Scale | ALL- ZES * (n = 25) |
PD for ZES * (n = 9) | DUODX + LAD for ZES * (n = 7) |
Thompson Procedure for ZES * (n = 9) | Non-PD Resections for ZES * (n = 16) |
p-Value (PD vs. Non-PD for ZES *) | PD for Any dpNEN # (n = 11) |
Non-PD Resection for Any dp-NEN # (n = 39) | p-Value (PD vs. Non-PD for All dpNEN) | General Population (Hinz 2014) |
|---|---|---|---|---|---|---|---|---|---|---|
| Global health/QoL | 64.6 | 76.9 | 59.5 | 57.4 | 58.3 | 0.1963 | 75.0 | 70.2 | 0.6271 | 75.7 |
| Physical functioning | 76.5 | 83.7 | 76.2 | 69.6 | 72.5 | 0.4489 | 84.2 | 82.3 | 0.7771 | 91.0 |
| Role functioning | 66.5 | 79.6 | 64.3 | 55.6 | 59.4 | 0.2327 | 80.3 | 76.2 | 0.9496 | 88.1 |
| Emotional functioning | 61.0 | 61.1 | 57.1 | 64.8 | 61.5 | 0.8191 | 58.2 | 67.6 | 0.2145 | 83.2 |
| Cognitive Functioning | 74.1 | 79.6 | 76.2 | 66.7 | 70.1 | 0.9246 | 77.3 | 81.9 | 0.3281 | 90.5 |
| Social Functioning | 64.7 | 72.2 | 57.1 | 64.8 | 61.5 | 0.7115 | 72.7 | 75.5 | 0.5223 | 91.5 |
| Fatigue | 37.1 | 25.9 | 39.7 | 45.7 | 43.1 | 0.2772 | 27.3 | 30.3 | 0.8269 | 19.5 |
| Nausea and Vomiting | 13.6 | 9.3 | 16.7 | 14.8 | 15.6 | 0.7415 | 9.1 | 9.6 | 0.6094 | 3.1 |
| Pain | 30.1 | 16.7 | 40.5 | 33.3 | 36.5 | 0.1798 | 16.7 | 19.3 | 0.7281 | 16.5 |
| Dyspnoea | 20.6 | 14.8 | 28.6 | 18.5 | 22.9 | 0.6178 | 12.1 | 15.6 | 0.8309 | 11.1 |
| Insomnia | 41.4 | 33.3 | 42.9 | 48.1 | 45.8 | 0.5519 | 30.3 | 32.6 | 0.8480 | 15.7 |
| Appetite Loss | 19.9 | 14.8 | 19.0 | 25.9 | 22.9 | 0.6809 | 12.1 | 14.5 | 0.6274 | 4.8 |
| Constipation | 25.2 | 7.4 | 28.6 | 3.7 | 14.6 | 0.3472 | 9.1 | 12.8 | 0.6569 | 5.2 |
| Diarrhoea | 32.6 | 37.0 | 23.8 | 37.0 | 31.3 | 0.6336 | 36.4 | 25.5 | 0.2616 | 4.9 |
| Financial Difficulties | 16.2 | 11.1 | 19.0 | 18.5 | 18.8 | 0.4134 | 15.2 | 17.7 | 0.9424 | 5.7 |
PD resection includes pylorus-preserving and pylorus-resecting partial pancreatectomy; non-PD resections include Thompson procedure, distal pancreatic resections with/without splenectomy, duodenotomy plus LAD, and enucleations; * intention to treat regarding the first operation in case of reoperations; # patients who underwent only 1 duodenopancreatic resection.