Table 1.

Carboplatin desensitisation protocol.

Premedication
1. Dexamethasone 19.8 mg in 50 mL NS infused over 30 min
2. Famotidine 20 mg, chlorpheniramine 5 mg, and palonosetron 0.75 mg in 50 mL NS infused over 30 min
Carboplatin Desensitisation
1. 1/1000 dilution in 250 mL 5% glucose infused over 60 min
2. 1/100 dilution in 225 mL 5% glucose infused over 60 min
3. 1/10 dilution in 225 mL 5% glucose infused over 60 min
4. Carboplatin AUC 5 or 6 in 225 mL 5% glucose infused over 60 min

NS: normal saline, min: minutes, AUC: area under the curve.