FIGURE 1 |.

The aging brain undergoes cerebral atrophy which describes the morphological shape changes observed in both healthy and pathological aging. They include neurodegeneration, cortical thinning, volume loss, white matter degeneration, sulcal widening, and ventricular enlargement. As we age, subcellular and cellular aging mechanisms gradually result in these organ-level changes that are visible in cross-sectional imaging studies. Gradually growing availability of longitudinal data provides new insight into progressive brain deterioration over several years and allows to quantify personalized progression of brain aging, underlying pathology, and its cognitive impact. Here, we show two coronal slices of a subject with severe Alzheimer’s disease from the Alzheimer’s disease Neuroimaging Initiative, that highlight their significant atrophy during a 3-year period.