FIGURE 2 |.

We create an anatomically accurate finite element model of the brain based on semi-automatic segmentation of a T1-weighted MRI. (A) The brain’s primary cortical and subcortical structures, as well as fluid volumes, are clearly visible in the representative sagittal, axial, and coronal slices shown here. (B) For the brain, we reconstruct the ventricles, white matter (WM), and gray matter (GM); we encase GM by cerebrospinal fluid (CSF) and approximate the skull by imposing zero-displacement boundary conditions on the CSF’s outer surface. (C) We create the GM layer by projecting the WM surface outward; this approach minimizes self-contact of the outer GM surface and provides an FE mesh that does not prevent sulcal widening due to shared nodes on the GM surface.