FIGURE 7 |.

Cross-sectional studies, with subjects covering many decades of life, provide insight into the transient brain volume changes and how they break down into the brain’s cortical and subcortical regions. Here, we compare our model’s predicted gray matter, white matter, and ventricular volume fraction with data reported by Coupe et al. (2019) for (A) healthy aging and (B) AD. In AD, we clearly observe a deviation from healthy aging in the form of accelerated atrophy. The grey area shows the loss of tissue volume that is replaced by fluid.