Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 13;14(8):1955. doi: 10.3390/cancers14081955

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Inhibition of mitoKv1.3 with PAPTP and PCARBTP triggers apoptosis in human multiple myeloma cell lines L-363 and RPMI-8226. (a) Dissipation of the mitochondrial membrane potential was monitored following the TMRM signal over time. CCCP was used as the positive control. (b) Mitochondrial ROS production was monitored by the development of MitoSOX fluorescence over time. Antimycin A was used as the positive control. Values are reported as percentage MFI with respect to solvent control. (c) Caspase 3/7-activation was measured by flow cytometry 4, 8 and 12 h after treatment with PAPTP (1 µM), PCARPTP (2 µM) or staurosporine (0.5 µM) as a positive control. Shown is the mean ± SD of % caspase 3/7+ cells of 3 independent experiments, each experiment in triplicate.