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. 2022 Apr 8;23(8):4144. doi: 10.3390/ijms23084144

Figure 6.

Figure 6

The tumor microenvironment accumulates collagens and forms fibrosis. The primary components of tumor fibrosis are fibrillar collagens, such as type I or type III collagen, and FACIT collagens, such as type XX collagen, are thought to organize the fibrillar collagens. Fragments of type XX collagen find their way to the circulation, where they can be detected in blood samples by a monoclonal antibody (mAb) raised against the C-terminus of type XX collagen and quantified in an ELISA. Figure made with BioRender.