TABLE 1.
AMB lipid formulations
| AMB formulation | Composition (molar ratio)a | AMB/lipids ratio (mol%) | Charge | Shape | Size (μm) |
|---|---|---|---|---|---|
| Liposomes | |||||
| AmBisome | HSPC/CHOL/DSPG/AMB (2:1:0.8:0.4) | 10 | Negative | Small unilamellar vesicles | 0.08 |
| Ampholiposomes | EPC/CHOL/SA/AMB (4:3:1:0.4) | 5 | Positive | Oligolamellar vesicles | 0.2–0.3 |
| Complexes | |||||
| Amphotec | CS/AMB (1:1) | 50 | Negative | Colloidal dispersion discs | 0.12 |
| Abelcet | DMPC/DMPG/AMB (7:3:5) | 33 | Negative | Lipid complexes (sheets) | 1–5 |
| LC-AMB | DMPC/DMPG/AMB (7:3:5) | 33 | Negative | Lipid complexes | 0.25 |
a
HSPC, hydrogenated soya phosphatidylcholine; CHOL, cholesterol; DSPG, distearoyl phosphatidylglycerol; EPC, egg yolk phosphatidylcholine; SA, stearylamine; CS, cholesteryl sulfate.