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Epigenetic toxicants in humans induce chromatin structure changes. Exposure to toxicants is associated with hypermethylation in cell cycle regulators genes, causing hyperproliferation and cell transformation. PAHS: Polycyclic aromatic hydrocarbons; PCBs: polychlorinated biphenyl; HATs: histone acetyltransferases; DNMT: DNA methyltransferases; HDAC: histone deacetyltransferases.
