Table 2.

Univariate Cox analysis for the incidence of major cardiac and cerebral events (MACCE) in diabetic and non-diabetic patients.

Prognostic Factors	Diabetic Patients		Non-Diabetic Patients
	HR (95% CI)	p-Value	HR (95% CI)	p-Value
microRNA
miR-1-3p	3.93 (0.57–27.06)	0.164	3.72 (1.21–11.5)	0.022
miR-122-5p	1.01 (0.99–1.02)	0.678	1.00 (0.99–1.01)	0.412
miR-124-3p	0.81 (0.40–1.64)	0.568	1.34 (0.76–2.38)	0.305
miR-133a-3p	2.13 (0.88–5.11)	0.089	0.89 (0.60–1.32)	0.573
miR-133b	0.87 (0.53–1.42)	0.581	0.98 (0.80–1.20)	0.862
miR-134-5p	1.04 (1.01–1.07)	0.020	1.05 (0.98–1.13)	0.140
miR-16-5p	1.01 (1.00–1.02)	0.048	1.0006 (1.0001–1.001)	0.019
miR-208b-3p	4.42 (0.87–22.25)	0.071	2.77 (0.84–9.15)	0.095
miR-34a-5p	0.41 (0.15–1.07)	0.070	1.04 (0.80–1.36)	0.749
miR-375	1.02 (0.98–1.06)	0.325	1.01 (0.99–1.02)	0.856
miR-499-5p	4.84 (1.07–21.89)	0.040	0.36 (0.02–11.13)	0.566
Demographic data
Age	1.02 (0.96–1.08)	0.457	1.02 (0.97–1.06)	0.375
Male gender	0.57 (0.19–1.69)	0.317	0.84 (0.36–1.97)	0.700
Hypertension	n.a.	n.a.	0.32 (0.09–1.08)	0.067
Hiperlipidemia	1.56 (0.20–11.89)	0.667	1.07 (0.37–3.13)	0.897
Smoking habit	1.12 (0.41–3.13)	0.817	1.69 (0.31–2.53)	0.369
CAD	1.38 (0.46–4.08)	0.558	0.97 (0.44–2.14)	0.956
LEAD	4.41 (1.57–12.42)	0.004	2.04 (0.91–4.55)	0.081
Prior MI	3.39 (1.13–10.20)	0.029	1.05 (0.39–2.82)	0.921
Renal artery stenosis	5.72 (1.20–27.21)	0.028	1.25 (0.49–3.15)	0.635
Laboratory results
Serum creatinine	1.02 (0.99–1.01)	0.056	1.00 (0.99–1.01)	0.646
C-Reactive Protein	1.10 (1.01–1.20)	0.025	0.96 (0.90–1.04)	0.392
Fibrinogen	1.25 (0.82–1.90)	0.309	0.60 (0.34–1.04)	0.070
LDL-cholesterol	0.90 (0.61–1.35)	0.617	1.37 (0.83–2.29)	0.221

CAD, Coronary Artery Disease; CI, Confidence Interval; HR, Hazard Ratio; LDL, Low Density Lipoprotein; LEAD, Lower Extremities Arterial Disease; MI, Myocardial Infarction.