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Metalloenzyme inhibition profiles for actinonin and BB-3497
| Compound | IC50 (nM)a for:
|
||||||
|---|---|---|---|---|---|---|---|
| PDF.Ni | MMP-1 | MMP-2 | MMP-3 | MMP-7 | Enkephalinase | ACE | |
| BB-3497 | 7 | 2,000 | 15,000 | >100,000 | >100,000 | 50,000 | >100,000 |
| Actinonin | 10 | 1,000 | 3,000 | 6,000 | 60%b | 7,000 | >100,000 |
MMP, matrix metalloproteinases; ACE, angiotensin I-converting enzyme.
Percent inhibition at 100 μM.
