TABLE 4.
In vitro activities of actinonin and BB-3497
| Bacterial straina | MIC (μg/ml) of:
|
|
|---|---|---|
| Actinonin | BB-3497 | |
| Staphylococcus aureus ATCC 29213 (MSSA) | 32 | 16 |
| Staphylococcus aureus ATCC 6538 (MSSA) | 32 | 4 |
| Staphylococcus aureus (MRSA) | 32 | 16 |
| Staphylococcus epidermidis ATCC 27626 | 2 | 4 |
| Enterococcus faecalis ATCC 29212 | 64 | 32 |
| Enterococcus faecalis (Vanr) | 128 | 8 |
| Streptococcus pneumoniae ATCC 49619 | 32 | 8 |
| Haemophilus influenzae ATCC 49247 | 2 | 0.25 |
| Escherichia coli ATCC 25922 | 64 | 8 |
| Escherichia coli TG1 (parent) | 128 | 8 |
| Escherichia coli TG1 (ΔacrB) | 1 | 0.125 |
| Escherichia coli D21 (parent) | 128 | 8 |
| Escherichia coli D22 (envA1) | 8 | 0.25 |
| Klebsiella pneumoniae ATCC 13883 | 128 | 8 |
| Enterobacter cloacae ATCC 13047 | >128 | 8 |
| Pseudomonas aeruginosa ATCC 27853 | 128 | 128 |
a
MSSA, methicillin-sensitive S. aureus; MRSA, methicillin-resistant S. aureus.