Table 1.
List of ncRNAs that have their production activated by HSF1-induced transcription. Note: For genes and RNAs we follow the recommendation of Seal and coauthors [18].
| ncRNA Production Activated by HSF1. | Length | Internal Repetitive Elements | Multiple Copies | HSE within Promoter Region | Genome Localization | Molecular Function in HS Cells |
|---|---|---|---|---|---|---|
| SATIII | from 2 kb to 5 kb and more | Yes (Tandem repeats, 5 b long) | Yes | Yes (in silico) | Multiple sites at heterochromatin pericentric regions | Titration of transcription factors |
| Reorientation of splicing decision | ||||||
| Maintenance of centromeric heterochromatin | ||||||
| Maintenance of repressive histone marks | ||||||
| Alu | ~280 b | No | Yes | Yes (ChIP) | Multiple and dispersed sites | RNAPII inhibition |
| Impact of gene expression through antisens RNA | ||||||
| Impact on transcriptional elongation | ||||||
| Recruitment of repressive transcriptional complexes | ||||||
| Alteration genome integrity through retrotransposition | ||||||
| eRNA | From 50 b to 2 kb | No | No | Yes (ChIP) | Multiple and dispersed sites | Control of gene expression |
| NEAT1 | ~3 kb (NEAT1-1) ~20 kb (NEAT1-2) |
No | No | Yes (ChIP) | Unique locus | miRNA biogenesis |
| HSP genes down regulation following HS | ||||||
| TERRA | From 100 b to less than 100 kb | Yes (Tandem repeats, 6 b unit) | Yes | Yes (ChIP) | Multiple sites at telomeres | Genome protection through telomere protection |
| Telomeric heterochromatin reformation by recruiting repressive chromatin marks |