Table 1.

Source, sponge host, extract/compound, cell line/organism tested and corresponding reference are reported.

Source	Associated Organisms	Extract/Compound	Cell Line/Organism Tested	Reference
Spongosorites sp. and S. ruetzleri		Topsentin and bromotopsentin	P388, HCT8, A549, T47	[44]
C. mollior		Cacospongiolide	Shrimp	[45]
R. sarai		Saraine A	A. salina	[47]
N. magnifica		Petroleum ether and total methanolic extracts	HepG2	[48]
N. magnifica		Aqueous ethanol extract	CACO-2 and MCF-7	[49]
Geodia sp.		Geodiamolide H 3	HOP 92, SF-268, OV Car-4, A498, UO-31, MDA-MB-231, HS 578T	[50]
G. cydonium		Methanolic extract	MCF-7, MDA-MB231, MDA-MB468	[52]
H. erectus		Oxysterol and 4′-methylheptyl benzoate	MCF-7 and HepG2	[53]
I. variabilis		Fasciculatin	MCF-7, NCI-H460 and SF-268	[54]
A. oroides and P. ficiformis		Methanolic extract	LAN5 and SK-N-BE(2)-C	[55]
T. aurantium, T. citrina, H.perlevis, I. variabilis, C. nucula, A. aerophoba and S. spinosulus		Aqueous extract	THP-1, CaCo-2 and BHK-21	[57]
P. gukhulensis		Gukulenin A	A2780, SKOV3, OVCAR-3 and TOV-21G	[58]
H. okadai		Lectin	Jurkat leukemia T and K562	[59]
P. ficiformis	Synechoccus sp. red and blue-green types, Cyanobium sp., Leptolyngbya cfr. Minuta, Leptolyngbya crf. ectocarpii, Leptolyngbya sp. 1, 2 and 3	Aqueous extract	A. salina and P. lividus	[62]
P. ficiformis	Cyanobium sp., Synechoccus sp., Pseudoanabaena sp. 1, 2, L. ectocarpi, Halomicronema cf. metazoicum, H. metazoicum	Aqueous cell supernatans	HeLa, SH-SY5Y and B-104-1-1	[63]
P. ficiformis	Streptomyces sp. SBT348	Petrocidin A	HL-60 and HT-29	[64]
A. oroides	Streptomyces sp. SBT345	Strepoxazine A	HL-60	[65]
H. fascigera	Trichophyton sp.	Ethil acetate extract	WiDr, T47D and HeLa	[66]
P. sollasi		Penazetidine A	PKC	[68]
S. aurantium		Hymenialdisines 4 and 5	PKC	[69]