TABLE 3.
Urinary metabolites, metric units, ng/mg Cr [range] (SI units, μmol/mol Cr) | Untransformed values | Log-transformed values | P a | ||
---|---|---|---|---|---|
Family history (n = 77) | No family history (n = 79) | Family history (n = 77) | No family history (n = 79) | ||
2OHE1 | 8.19 ± 0.55 | 7.83 ± 0.53 | 0.839 ± 0.03 | 0.824 ± 0.03 | 0.73 |
[0.34–26.14] | [1.61–24.41] | ||||
(3.19 ± 0.21) | (3.09 ± 0.21) | ||||
2MeOE1 | 4.20 ± 0.27 | 4.09 ± 0.27 | 0.562 ± 0.03 | 0.551 ± 0.03 | 0.77 |
[0.47–12.77] | [0.92–10.66] | ||||
(1.62 ± 0.11) | (1.65 ± 0.11) | ||||
16αOHE1 | 4.18 ± 0.32 | 4.46 ± 0.31 | 0.538 ± 0.03 | 0.580 ± 0.03 | 0.34 |
[0.44–14.84] | [1.42–18.99] | ||||
(1.63 ± 0.12) | (1.76 ± 0.12) | ||||
E3 | 7.30 ± 0.95 | 7.37 ± 0.91 | 0.783 ± 0.03 | 0.734 ± 0.03 | 0.31 |
[1.07–22.67] | [0.87–14.92] | ||||
(2.82 ± 0.37) | (2.89 ± 0.36) | ||||
2OHE1/16αOHE1 | 2.28 ± 0.13 | 1.19 ± 0.13 | 0.303 ± 0.03 | 0.226 ± 0.03 | 0.04 |
[0.53–7.48] | [0.33–4.84] | ||||
2.26 ± 0.14 | 1.98 ± 0.14 | ||||
2MeOE1/16αOHE1 | 1.13 ± 0.05 | 1.00 ± 0.05 | 0.024 ± 0.02 | −0.036 ± 0.02 | 0.03 |
[0.36–3.51] | [0.23–2.24] | ||||
6.32 ± 0.77 | 6.06 ± 0.76 | ||||
Total metabolites | 23.88 ± 1.66 | 23.74 ± 1.60 | 1.32 ± 0.03 | 1.31 ± 0.03 | 0.75 |
[2.67–56.86] | [5.96–63.45] | ||||
(9.29 ± 0.64) | (9.37 ± 0.63) | ||||
Serum E2 (pg/ml) (SI, pmol/liter) | 13.80 ± 0.70 | 15.07 ± 0.61 | |||
(52.20 ± 2.54) | (54.43 ± 2.22) | 0.17 |
The molecular weight of the different metabolites used in the conversion to SI units is as follows: 2OHE1 and 16αOHE1, 286.4; 2MeOE1, 284.4; and E3, 288.4. The conversion factors for urinary Cr and serum E2 are 88.4 and 3.671, respectively. Values are the mean ± SE [range].
Determined by ANOVA adjusted for age and YSM for urinary metabolite comparisons.