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Model-informed precision dosing workflow. MIC determination is performed on day 1 of treatment and PK sampling on days 1, 8, and 15. A Bayesian forecast is then performed using the population PK model, patient characteristics, and individual linezolid plasma concentrations. Taking efficacy and safety into account, the dose is adjusted one week after PK sampling. MIC, minimal inhibitory concentration; PK, pharmacokinetics.
