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. 2022 Apr 22;8(16):eabj1664. doi: 10.1126/sciadv.abj1664

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Fig. 5. — (A) AML state-transition trajectories from miRNA and mRNA state-spaces over time reveal similarities in dynamics for individual CM mice. (B) Hierarchical clustering of a correlation matrix constructed with time-series expression of five AML-promoting genes identified in our previous work (Prkd1, Egfl7, Wt1, Kit, and Cbfb-MYH11) and persistent DE miRNAs that had the largest positive and negative contribution to AML. Positive and negative correlations between miRNAs and mRNA genes involved in AML state-transition are consistent with the state-space and mathematical model predictions. The largest positive correlation between the miRNAs and the five mRNA genes was between the miRNA that had a positive contribution to AML and the AML-promoting genes.