Table 1.

MafA target genes. (*) denotes evidence that MafA directly binds target gene promoter.

Gene Symbol	Gene Name	Gene Function	Reference
Cacng4 *	Voltage-dependent calcium channel gamma-4 subunit	Enhances L-type Ca2+-mediated Ca2+ entry into β-cell	[45]
Chrnb4 *	Cholinergic receptor nicotinic beta 4	Subunit of the nicotinic acetylcholine receptor	[46]
Cox6a2 *	Cytochrome C oxidase subunit 6A2	One out of 13 subunits of cytochrome C oxidase complex (Complex IV), the last enzyme in the electron transport chain	[47]
G6pc2 *	Glucose-6-phosphate catalytic subunit related protein	Islet-specific enzyme that hydrolyzes glucose-6-phosphate, limits basal insulin secretion	[48]
Gck	Glucokinase	Phosphorylates glucose to glucose-6-phosphate in pancreatic islets and hepatocytes. Considered the β-cell glucose sensor	[49]
Glp1r	Glucagon-like peptide 1 receptor	Receptor for Glucagon-like peptide 1 (Glp1), a stimulator of insulin secretion	[49]
Ins1 *	Insulin I	One of two insulin genes in mouse, on chromosome 19	[11]
Ins2 *	Insulin II	One of two insulin genes in mouse, on chromosome 7	[11]
Maob *	Monoamine oxidase B	Metabolizes monoamine neurotransmitters, specifically benzylamine, dopamine and phenylethylamine	[50]
Neurod1	Neurogenic differentiation 1	Transactivator of genes important for β-cell maturation and function, including insulin	[49]
Nkx6.1	NK6 homeobox1	TF involved in β-cell development and regulation of genes involved in mature β-cell function	[49,51]
Pcsk1	Proprotein convertase subtilisin/kexin type 1	Proprotein convertase, which processes proinsulin in β-cells	[49]
Pcx	Pyruvate carboxylase	Catalyzes the conversion of pyruvate to oxaloacetate	[49]
Pdx1 *	Pancreatic and duodenal homeobox 1	TF important pancreas development and for mature β-cell function	[49,52]
PPP1R1A	Protein phosphatase 1, regulatory inhibitor subunit 1A	Regulates cAMP/PKA signaling pathway Promotes Glp1-induced GSIS	[53]
Prlr	Prolactin Receptor	Involved in increasing β-cell mass during pregnancy	[54]
Slc2a2 *	Solute Carrier Family 2 Member 2	Glucose transporter 2, transmembrane glucose transporter with a high Km for glucose	[49,55]
Slc80a8	Solute carrier family 30 member 8	Zinc transporter on insulin granules in β-cells	[19,46]