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. 2022 Mar 30;10(4):809. doi: 10.3390/biomedicines10040809

Figure 4.

Figure 4

Abundances of KEGG pathway modules were found to be significant using Kruskal–Wallis multivariate analysis related to bile acid synthesis. (A) Relative abundance of the choloylglycine hydrolase gene in the sHF, mHF, and Sham samples (Kruskal–Wallis test p-value = 0.0037). (n values are as follows: Sham = 9, mHF = 7, sHF = 6). (B) Relative abundance of the choloylglycine hydrolase gene in the Sham and TAC samples at different time points showing an increase in the concentration of the gene with time in TAC samples as compared to Sham samples (Kruskal–Wallis test p-value = 0.23 for Sham samples and p-value = 0.01 for TAC samples). (n values are as follows: Sham day 0 = 10, day 7 = 10, day 14 = 9, day 42 = 9; TAC day 0 = 16, day 7 = 16, day 14 = 16, day 42 = 15). (C) Relative abundance of 7-α-hydroxysteroid dehydrogenase gene in the sHF, mHF, and Sham samples with a significant decrease in sHF and mHF compared to the Sham samples (Kruskal–Wallis test p-value = 0.042). (n values are as follows: Sham = 9, mHF = 7, sHF = 6). (D) Relative abundance of 7-α-hydroxysteroid dehydrogenase gene in the Sham and TAC samples at different time points with a significant decrease in abundance with time in the TAC samples (Kruskal–Wallis test p-value = 0.0025). (n values are as follows: Sham day 0 = 10, day 7 = 10, day 14 = 9, day 42 = 9; TAC day 0 = 16, day 7 = 16, day 14 = 16, day 42 = 15). *, **, and *** correspond to p ≤ 0.05, p ≤ 0.01, and p ≤ 0.001, respectively; ns, non-significant.