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. 2022 Apr 8;11(8):1262. doi: 10.3390/cells11081262

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SMYD2 inhibition decreases TMPRSS2 expression in Calu-3 cells. (A–D) LDH release from Vero E6 (A,B) and Calu-3 cells (C,D) stimulated with the indicated concentrations of the respective inhibitor for 24 h (A,C) or 48 h (B,D). Experiments were performed two times and representative data are shown. *** p < 0.001. * p < 0.05. N.S., not significant. (E) Immunoblot analysis of TMPRSS2 in lysates of Calu-3 cells incubated with 20 µM BAY598 for the indicated time points. Caco-2 cells served as a positive control, while Vero E6 cells were used as a negative control. β-Actin was stained as the loading control. (F) Densitometric analysis of TMPRSS2 expression levels in Calu-3 cells.