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. 2022 Apr 8;11(8):1262. doi: 10.3390/cells11081262

Figure 7.

Figure 7

Inhibition of SMYD2 in Calu-3 cells slightly impedes SARS-CoV-2 replication. (A,B) Antiviral effect of AZ505 and BAY598 in Calu-3 cells. Cells were treated with the indicated concentrations for 24 h prior to infection. The same amount of inhibitor was also applied together with the virus (MOI = 0.005). SARS-CoV-2 positive cells were visualized two days post-infection using a mAb against Spike and an Alexa488-conjugated secondary antibody under a Nikon Inverted Ts2-FL Eclipse microscope equipped with a 10× objective. The Alexa488 signal was quantified in a Victor X4 multilabel reader. Bar graphs represent mean values of eight infected wells ± SD. ** p < 0.01. * p < 0.05. N.S., not significant. One representative experiment out of three replicates is shown.