Table 2.
Metabolism and maximum uptake of the ML-compounds in A431 tumors.
| Tracer | Animal | Metabolism | Method | Maximum Uptake in A431 Xenografts |
|---|---|---|---|---|
| 1 | BALB cBy nu/nu male mice |
Extractable fraction in blood: 16% Intact tracer in the fraction: 75% at 20 min |
Radio-TLC [48] | Ex vivo: 1.34 ± 0.79%ID/g T/B 1.62 ± 0.68 at 60 min [48] |
| 2 | BALB cBy nu/nu male mice |
Extractable fraction in blood: 36% Intact tracer in the fraction: 56% at 10 min |
Radio-TLC [48] | Ex vivo: 2.90 ± 1.67%ID/g T/B 0.89 ± 0.63 at 5 min In vivo: T/B ratio of 0.55, T/M ratio of 0.83 at 10 min [48] |
| 3 | WAG rnu/rnu male rats |
Extractable fraction in blood: 32% Intact tracer in the fraction: 90% at 15 min Extractable fraction in blood: 17% Intact tracer in the fraction: 75% at 60 min |
Radio-TLC [49] | Ex vivo: 0.09 ± 0.039%ID/g T/B 0.54 ± 0.04 at 15 min In vivo: T/B 2.86, T/M 4.61 at 120 min [49] |
| Nude Hsd:RH-rnu/rnu male rats | Intact tracer in blood: 29% at 15 min * Intact tracer in blood: 13% at 60 min * |
Radio-TLC [50] | ND | |
| 4 | Nude Hsd:RH-rnu/rnu male rats | Intact tracer in blood: 40% at 15 min * Intact tracer in blood: 38% at 60 min * | Radio-TLC [50] | ND |
* Reviewer estimated values, ND = not determined.