Table 3.
Results of GO overrepresentation analyses for transcripts related to BMI SDS.
| Gene Set | Description | Size | Enrichment Ratio |
FDR |
|---|---|---|---|---|
| Adipose tissue | ||||
| GO:0050900 | leukocyte migration | 413 | 3.9 | 8.2 × 10−5 |
| GO:1901615 | organic hydroxy compound metabolic process | 494 | 3.6 | 8.2 × 10−5 |
| GO:0008202 | steroid metabolic process | 302 | 4.3 | 3.0 × 10−4 |
| GO:0006898 | receptor-mediated endocytosis | 279 | 4.1 | 2.0 × 10−3 |
| GO:0044282 | small molecule catabolic process | 419 | 3.3 | 3.0 × 10−3 |
| GO:0043062 | extracellular structural organisation | 392 | 3.3 | 3.7 × 10−3 |
| GO:0002446 | neutrophil-mediated immunity | 484 | 3.0 | 3.7 × 10−3 |
| GO:0036230 | granulocyte activation | 488 | 3.0 | 3.7 × 10−3 |
| GO:0060326 | cell chemotaxis | 285 | 3.7 | 5.1 × 10−3 |
| GO:0062012 | regulation of small molecule metabolic process | 338 | 3.4 | 6.7 × 10−3 |
| Adipocytes | ||||
| GO:0043062 | extracellular structural organisation | 392 | 6.2 | 7.6 × 10−13 |
| GO:0006898 | receptor-mediated endocytosis | 279 | 4.1 | 4.1 × 10−3 |
| GO:0050900 | leukocyte migration | 413 | 3.3 | 4.1 × 10−3 |
| GO:0007492 | endoderm development | 72 | 7.9 | 5.8 × 10−3 |
| GO:0071559 | response to transforming growth factor beta | 234 | 4.2 | 5.8 × 10−3 |
| GO:0006638 | neutral lipid metabolic process | 118 | 5.5 | 1.2 × 10−2 |
| GO:0048771 | tissue remodelling | 151 | 4.8 | 1.2 × 10−2 |
| GO:0002526 | acute inflammatory response | 153 | 4.8 | 1.2 × 10−2 |
| GO:0016042 | lipid catabolic process | 310 | 3.4 | 1.2 × 10−2 |
| GO:0050673 | epithelial cell proliferation | 359 | 3.2 | 1.2 × 10−2 |
| Stromal vascular fraction cells | ||||
| GO:0050900 | leukocyte migration | 413 | 6.2 | 1.9 × 10−13 |
| GO:0036230 | granulocyte activation | 488 | 5.6 | 1.9 × 10−13 |
| GO:0002446 | neutrophil-mediated immunity | 484 | 5.1 | 3.6 × 10−11 |
| GO:0002237 | response to molecule of bacterial origin | 326 | 5.6 | 1.3 × 10−8 |
| GO:0002694 | regulation of leukocyte activation | 473 | 4.6 | 1.6 × 10−8 |
| GO:0071216 | cellular response to biotic stimulus | 221 | 6.7 | 2.3 × 10−8 |
| GO:0002521 | leukocyte differentiation | 489 | 4.4 | 2.3 × 10−8 |
| GO:0060326 | cell chemotaxis | 285 | 5.8 | 2.6 × 10−8 |
| GO:0050727 | regulation of inflammatory response | 358 | 5.1 | 3.7 × 10−8 |
| GO:0006909 | phagocytosis | 234 | 6.4 | 3.9 × 10−8 |
From all significantly (False discovery rate FDR ≤ 5%) associated transcripts, the 250 transcripts with the highest absolute effect sizes were considered. BMI SDS, body mass index standard deviation score; GO, gene ontology.