Figure 4.
Endothelial serum marker kinetics (validation cohort, n = 47). Patients were grouped according to CRS and ICANS grade with analysis of endothelial markers (ST2, ANG2, sCD141, and IL8) prior to lymphodepletion and on day 7 after application. CRS and/or ICANS grades 0-2 (n = 39) and ≥ 3 (n = 8). EASIX, Endothelial Activation and Stress Index; ST2, suppressor of tumorigenicity 2; ANG2, Angiopoietin-2; sCD141, soluble thrombomodulin; IL8, interleukin 8; pre, prior lymphodepletion; d, day.