Table 3.

Multivariable logistic regression (Firth correction) with the EASIX cutoff (categorial) (Validation cohort, n = 121, 21 events).

Binary Endpoint: CRS/ICANS ≥ 3	OR (95% CI)	p-value
EASIX-pre (cutoff >4.67)	4.32 (1.52–12.67)	0.006
Age (per 10 years)	0.93 (0.66–1.35)	0.709
Gender male vs. female	4.56 (1.27–24.81)	0.018
Diagnosis (aggr. B-cell lymphoma vs. other)	1.07 (0.35–3.68)	0.905
Disease status at lymphodepletion	1.50 (0.50–4.91)	0.478

EASIX, Endothelial Activation and Stress Index; pre, prior lymphodepletion; log, logarithm; CRS, cytokine release syndrome; ICANS, immune effector cell-associated neurotoxicity syndrome; OR, odds ratio; 95% CI, 95 percent confidence interval.

Diagnosis patients with aggressive B-cell lymphoma vs. other. Disease status: patients with progressive or refractory disease vs. patients with stable disease or response (complete or partial).