Table 3.
RR of hospitalisation due to infection with SARS-CoV-2 omicron variant according to COVID-19 vaccination status, with unvaccinated individuals with delta infection as a reference, among 188 980 cases between Nov 21 and Dec 19, 2021, in Denmark
|
Not hospitalised |
Hospitalised |
Crude RR |
Adjusted RR |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Delta (n=148 098) | Omicron (n=38 447) | Delta (n=2213) | Omicron (n=222) | Delta | Omicron | p value | Delta | Omicron | p value | |
| None or one dose | 68 888/76 100 (90·5%) | 7212/76 100 (9·5%) | 997/1051 (94·9%) | 54/1051 (5·1%) | 1 (ref) | 0·52 (0·40–0·68) | <0·0001 | 1 (ref) | 0·57 (0·44–0·75) | <0·0001 |
| Two doses | 76 400/106 177 (72·0%) | 29 777/106 177 (28·0%) | 1041/1186 (87·8%) | 145/1186 (12·2%) | 0·94 (0·86–1·03) | 0·34 (0·29–0·40) | .. | 0·23 (0·21–0·26) | 0·17 (0·14–0·20) | .. |
| Three doses | 2810/4268 (65·8%) | 1458/4268 (34·2%) | 175/198 (88·4%) | 23/198 (11·6%) | 4·11 (3·51–4·81) | 1·09 (0·72–1·64) | .. | 0·33 (0·28–0·40) | 0·17 (0·11–0·25) | .. |
Data are n/N (%) or RR (95% CI). p values in the stratified analysis are tests for interaction terms. Adjusted RRs were adjusted for the basic (a priori) covariates sex, age (10-year groups), sample period as a continuous variable (week 46+47, 48, 49, or 50), region (capital, central Denmark, north Denmark, Zealand, or southern Denmark), comorbidities in the preceding 5 years (none vs one or more), and previous SARS-CoV-2 infection more than 60 days earlier. RR=risk ratio.