Fig. 11. Binding energies of the metabolites dereplicated in Sabal-derived extracts. All metabolites (yellow color) except for the non-glycosylated flavonoids (green color, more than 10) showed binding energies less than −8 kcal mol⁻¹. Galantamine and donepezil (i.e. the co-crystalized ligands of AChE, red color) showed binding energies of −9.0 and −8.7 kcal mol⁻¹.