TABLE 1.

Estimated compartmental pharmacokinetic parameters of caspofungin in plasma^a

Drug dose (mg/kg)	Cmax (μg/ml)	Cmin (24 h) (μg/ml)	AUC0–∞ (μg/ml · h)	Vss (liter/kg)	CL (liter/h/kg)	t1/2αb (h)	t1/2β (h)	t1/2γ∗ (h)
Single dose
1	20.02 ± 1.18	0.00 ± 0.00	20.57 ± 0.89	0.239 ± 0.011	0.050 ± 0.002	0.09 ± 0.00	2.00 ± 0.06	31.61 ± 0.12
3	60.47 ± 8.49	0.00 ± 0.00	47.14 ± 3.60	0.277 ± 0.033	0.068 ± 0.005	0.05 ± 0.00	1.84 ± 0.07	30.23 ± 1.19
6	123.40 ± 5.17	0.10 ± 0.00	119.30 ± 10.91	0.275 ± 0.006	0.053 ± 0.006	0.11 ± 0.01	1.85 ± 0.14	26.19 ± 1.29
Multiple dose
1	16.01 ± 0.61	0.00 ± 0.00	13.15 ± 2.37	0.299 ± 0.011	0.086 ± 0.017	0.09 ± 0.01	1.62 ± 0.21	31.87 ± 0.18
3	51.05 ± 4.59	0.18 ± 0.18	63.70 ± 21.34	0.378 ± 0.050	0.065 ± 0.015	0.09 ± 0.01	2.20 ± 0.37	34.77 ± 3.09
6	105.52 ± 8.92	0.63 ± 0.26	158.43 ± 15.58	0.351 ± 0.016	0.043 ± 0.004	0.10 ± 0.00	3.53 ± 0.48	30.86 ± 0.96

^aAll values represent the means ± standard errors of the means of values three rabbits each. Abbreviations: C_{min(24 h)}, plasma concentration at the end of the dosing interval (24 h); t_1/2α distributional half-life; t_1/2β, apparent elimination half-life; t_1/2γ, terminal elimination half-life. 

^bP ⩽ 0.05 for the comparison among dosage groups by ANOVA.