Table 2.
Association between STAT3 expression and clinical features of thyroid cancer patients in meta-analysis.
| Factors | Studies (n) | Analytical model | OR (95%CI) | P value | Heterogeneity | |
|---|---|---|---|---|---|---|
| I 2 | P h | |||||
| Age (<45 vs ≥ 45) | 4 | REM | 0.54 (0.21, 1.36) | 0.191 | 64.00 | 0.039 |
| Sex (male vs female) | 4 | FEM | 0.88 (0.54, 1.44) | 0.609 | 0 | 0.898 |
| Tumor size (≤1 cm vs. > 1 cm) | 2 | FEM | 0.13 (0.05, 0.33) | <0.001 | 0 | 0.743 |
| Tumor metastasis (yes vs. no) | 6 | REM | 2.83 (1.08, 7.46) | 0.035 | 80.70 | <0.001 |
| Capsular invasion (yes vs. no) | 2 | REM | 2.98 (0.23, 38.29) | 0.403 | 89.60 | 0.002 |
| TNM stage (I-II vs. III-IV) | 3 | REM | 0.40 (0.24, 0.67) | <0.001 | 82.10 | 0.004 |
| Tumor multiplicity (single vs. multiplicity) | 2 | REM | 0.25 (0.003, 19.28) | 0.533 | 86.00 | 0.008 |
P values were obtained by using the “METAN” program in Stata 14.0; P value 0.05 was considered as statistically significant. FEM, fixed-effects model; REM, random-effects model; TNM, tumor node metastasis; OR, odds ratio; CI, confidence interval. Bold fonts indicate statistical differences.