TABLE 1.

Serum voriconazole concentrations^a

Dose	Serum voriconazole concn (μg/ml)
	Day 11	Day 23
5 mg/kg/day	1.6 ± 0.2	2.2 ± 0.1
20 mg/kg/day	1.6 ± 0.2	1.7 ± 0.1
40 mg/kg/day	4.7 ± 0.2	4.4 ± 0.1
40 mg/kg three times/wk	1.6 ± 0.2	2.8 ± 0.5

^aValues are means ± standard deviations of values obtained from six mice at each time point. Blood was obtained on day 11 (midtreatment, approximately 4 h after dosing) and day 23, 2 days after treatment was stopped. Day 11 was Thursday, and thus, mice in the group that received voriconazole at 40 mg/kg three times per week (on Mondays, Wednesdays, and Fridays) received voriconazole approximately 24 h earlier.