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. 2022 Apr 15;2022:3985621. doi: 10.1155/2022/3985621

Figure 4.

Figure 4

miR-144-3p inhibition abates the effects of circKIF4A knockdown in GC cells. (a) The predicted binding sites between EZH2 mRNA and miR-144-3p. (b) Dual-luciferase reporter assay for the binding relation between EZH2 mRNA and miR-144-3p. (c) Western blot analysis of EZH2, E-cadherin, N-cadherin, and Vimentin protein expression in GC cells with circKIF4A knockdown after miR-144-3p inhibition. (d) MTT assay for the proliferation of GC cells with circKIF4A knockdown after miR-144-3p inhibition/EZH2 restoration. (e) Transwell assay for the migration and invasion of GC cells with circKIF4A knockdown after miR-144-3p inhibition/EZH2 restoration. ∗P < 0.05 vs. NC mimics or si-NC-transfected cells; #P < 0.05 vs. NC inhibitor or empty vector-transfected cells.