Scheme 1. Synthesis of chiral amidine 2a. Reagents and conditions: (a) PhCOCl, NaOH, H2O, 0 °C to rt; (b) (COCl)2, 2,6-lutidine, dry CH2Cl2, 0 °C to rt; (c) 3, reflux.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.