Analysis of variance (ANOVA) for DH (Y₁), and IC₅₀ of lipase inhibition (Y₂) via the response surface quadratic model.

Source	df	Y 1				Y 2
		Sum of square	Mean square	F-value	P-value	Sum of square	Mean square	F-value	P-value
Model	9	211.46	23.50	24.59	<0.0001a	619.70	68.86	107.72	<0.0001a
X 1	1	24.21	24.21	25.34	0.0005a	9.58	9.58	14.99	0.0031a
X 2	1	119.66	119.66	125.23	<0.0001a	18.60	18.60	29.10	0.0003a
X 3	1	37.63	37.63	39.38	<0.0001a	60.83	60.83	95.17	<0.0001a
X 1 X 2	1	1.30	1.30	1.36	0.2698	33.88	33.88	53.01	<0.0001a
X 1 X 3	1	4.85	4.85	5.08	0.0479a	8.39	8.39	13.13	0.0047a
X 2 X 3	1	0.01	0.01	0.01	0.9185	71.90	71.90	112.48	<0.0001a
X 1 2	1	15.28	15.28	15.99	0.0025a	316.33	316.33	494.90	<0.0001a
X 2 2	1	2.15	2.15	2.25	0.1645	91.64	91.64	143.37	<0.0001a
X 3 2	1	10.05	10.05	10.52	0.0088a	74.49	74.49	116.54	<0.0001a
Residual	10	9.55	9.56			6.39	0.6392
Lack of fit	5	6.81	1.36	2.49	0.1701	3.69	0.7388	1.39	0.3694
Pure error	5	2.74	0.55			2.70	0.5396
Cor total	19	221.01				626.09
Std dev.		0.9775				0.7995
R 2		0.9568				0.9898
Adj R2		0.9179				0.9806

^aIndicates those variables which significantly influence the response variables (p < 0.05).