TABLE 1.

MICs for germinated and nongerminated conidia of Aspergillus spp. obtained by the NCCLS broth microdilution method^a

Species (no. of strains tested) and antifungal agent	MIC (MIC90) [μg/ml]
	Germinated	Nongerminated
A. flavus (12)
Amphotericin B	0.2–2 (2)	0.5–2 (2)
Itraconazole	0.03–0.2 (0.2)	0.03–0.5 (0.2)
Voriconazole	0.12–0.5 (0.5)	0.12–0.5 (0.5)
Posaconazole	0.12–1.0 (0.5)	0.03–0.5 (0.5)
Ravuconazole	0.12–0.5 (0.5)	0.12–1.0 (1.0)
A. fumigatus (30)
Amphotericin B	0.2–2 (2)	0.5–2 (2)
Itraconazole	0.01–>8 (0.5)	0.03–>8 (0.2)
Voriconazole	0.12–1.0 (0.5)	0.06–1.0 (0.5)
Posaconazole	0.06–1.0 (0.12)	0.03–1.0 (0.2)
Ravuconazole	0.06–8 (0.5)	0.12–8 (1.0)
A. nidulans (10)
Amphotericin B	0.2–4 (1.0)	0.2–4 (1.0)
Itraconazole	0.01–0.5 (0.2)	0.01–0.5 (0.5)
Voriconazole	0.01–2 (0.2)	0.01–0.5 (0.2)
Posaconazole	0.03–0.5 (0.12)	0.06–0.2 (0.12)
Ravuconazole	0.03–2 (0.2)	0.06–2 (0.5)
A. niger (7)
Amphotericin B	0.2–0.5 (0.5)	0.5–1.0 (1.0)
Itraconazole	0.06–1.0 (0.5)	0.12–1.0 (0.2)
Voriconazole	0.12–0.5 (0.5)	0.12–1.0 (1.0)
Posaconazole	0.2–1.0 (0.5)	0.2–0.5 (0.5)
Ravuconazole	0.5–4 (4)	0.5–4 (4)
A. sydowii (1)
Amphotericin B	0.12 (NDb)	0.12 (ND)
Itraconazole	0.2 (ND)	0.5 (ND)
Voriconazole	0.12 (ND)	0.12 (ND)
Posaconazole	0.5 (ND)	0.2 (ND)
Ravuconazole	0.12 (ND)	0.2 (ND)
A. terreus (12)
Amphotericin B	1.0–2 (2)	0.5–4 (4)
Itraconazole	0.01–0.5 (0.2)	0.03–0.5 (0.2)
Voriconazole	0.12–1.0 (1.0)	0.06–1.0 (1.0)
Posaconazole	0.03–0.5 (0.5)	0.01–0.5 (0.5)
Ravuconazole	0.2–1.0 (1.0)	0.12–1.0 (2)

^aNCCLS M38-P method for antifungal susceptibility (MICs) testing of opportunistic mold pathogens. 

^bND, not determined.