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. 2021 May 27;11(31):19203–19220. doi: 10.1039/d1ra01913a

A comparison of the atom economy and atomic efficiency of the present methodology with other methods for the synthesis of 5-substituted-1H-tetrazole derivatives.

Entry Equation Desired product Time (h) Yielda (%) AE (%) AEf
1 1 graphic file with name d1ra01913a-u45.jpg 8 78 71.58 51.24
2 7 91 65.13
3 4 92 65.85
4 1 h 30 min 96 68.71
5 15 min 97 69.43
2 1 graphic file with name d1ra01913a-u46.jpg 9 88 76.72 67.51
2 8 92 70.58
3 3 96 73.65
4 1 h 20 min 96 73.65
5 15 min 97 74.41
3 1 graphic file with name d1ra01913a-u47.jpg 75.23
2 8 90 67.07
3 5 90 67.07
4 2 h 30 min 87 65.45
5 10 min 98 73.72
a

Isolated yield.