A comparison of the atom economy and atomic efficiency of the present methodology with other methods for the synthesis of 5-substituted-1H-tetrazole derivatives.
Entry | Equation | Desired product | Time (h) | Yielda (%) | AE (%) | AEf |
---|---|---|---|---|---|---|
1 | 1 | 8 | 78 | 71.58 | 51.24 | |
2 | 7 | 91 | 65.13 | |||
3 | 4 | 92 | 65.85 | |||
4 | 1 h 30 min | 96 | 68.71 | |||
5 | 15 min | 97 | 69.43 | |||
2 | 1 | 9 | 88 | 76.72 | 67.51 | |
2 | 8 | 92 | 70.58 | |||
3 | 3 | 96 | 73.65 | |||
4 | 1 h 20 min | 96 | 73.65 | |||
5 | 15 min | 97 | 74.41 | |||
3 | 1 | — | — | 75.23 | — | |
2 | 8 | 90 | 67.07 | |||
3 | 5 | 90 | 67.07 | |||
4 | 2 h 30 min | 87 | 65.45 | |||
5 | 10 min | 98 | 73.72 |
Isolated yield.