A comparison of the atom economy and atomic efficiency of the present methodology with other methods for the synthesis of 1-substituted-1H-tetrazole derivatives.
Entry | Equation | Desired product | Time (h) | Yielda (%) | AE (%) | AEf |
---|---|---|---|---|---|---|
1 | 6 | 5 | 67 | 47.70 | 31.95 | |
7 | 1 | 92 | 43.88 | |||
8 | 40 min | 92 | 43.88 | |||
9 | 4 h 30 min | 78 | 37.20 | |||
10 | 20 min | 98 | 46.74 | |||
2 | 6 | 4 | 77 | 54.40 | 41.88 | |
7 | 3 | 75 | 40.80 | |||
8 | 1 h 10 min | 92 | 50.04 | |||
9 | — | — | — | |||
10 | 45 min | 80 | 43.52 | |||
3 | 6 | 6 | 92 | 52.37 | 48.18 | |
7 | 1 | 96 | 50.27 | |||
8 | 1 | 93 | 48.70 | |||
9 | — | — | — | |||
10 | 15 min | 97 | 50.79 |
Isolated yield.