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. 2021 May 27;11(31):19203–19220. doi: 10.1039/d1ra01913a

A comparison of the atom economy and atomic efficiency of the present methodology with other methods for the synthesis of 1-substituted-1H-tetrazole derivatives.

Entry Equation Desired product Time (h) Yielda (%) AE (%) AEf
1 6 graphic file with name d1ra01913a-u48.jpg 5 67 47.70 31.95
7 1 92 43.88
8 40 min 92 43.88
9 4 h 30 min 78 37.20
10 20 min 98 46.74
2 6 graphic file with name d1ra01913a-u49.jpg 4 77 54.40 41.88
7 3 75 40.80
8 1 h 10 min 92 50.04
9
10 45 min 80 43.52
3 6 graphic file with name d1ra01913a-u50.jpg 6 92 52.37 48.18
7 1 96 50.27
8 1 93 48.70
9
10 15 min 97 50.79
a

Isolated yield.