Fig. 1. Overview of the T2R-TTL-ligand complex structure and the chemical structures of the bound ligands. (A) Overall structure of the tubulin–ELR510444 complex. RB3-SLD is shown in yellow, TTL in blue, α-tubulin in green, β-tubulin in pink, GTP in red, GDP in grey, and ELR510444 in cyan. GTP, GDP, and ELR510444 are shown as spheres. (B) Chemical structure of ELR510444. (C) Experimental electron density map (Fo–Fc) contoured at 2.0 σ around ELR510444. (D) Chemical structure of parbendazole. (E) The electron densities of parbendazole. The Fo–Fc omit map is shown in grey and contoured at 1.5 σ.
