Table 1.

Overlapping conditions and misdiagnosis of ATTR amyloidosis

Cardiac [27–29]

Neurologic [3, 24, 25]

• Heart failure with preserved ejection fraction • Hypertensive cardiomyopathy • Aortic stenosis • Hypertrophic cardiomyopathy • Light chain amyloidosis with cardiac involvement • Idiopathic restrictive cardiomyopathy • Iron overload • Other infiltrative cardiomyopathies (e.g., Fabry disease)

• Chronic inflammatory demyelinating polyneuropathy • Paraproteinemic peripheral neuropathy (e.g., monoclonal gammopathy-associated) • Toxic peripheral neuropathy • Vasculitic peripheral neuropathy • Idiopathic axonal polyneuropathy • Paraneoplastic neuropathy • Diabetic neuropathy • Alcoholic neuropathy • Motor neuron disease (e.g., amyotrophic lateral sclerosis) • Fibromyalgia • Light chain amyloidosis

ATTR amyloid transthyretin