Table 2.

Signs and symptoms that should raise suspicion of ATTR amyloidosis with cardiomyopathy

Signs/symptoms
Heart failure with predominant right-sided symptoms (e.g., distended jugular veins, anorexia, gastrointestinal upset, dependent edema, weight gain)
HFpEF, especially in men
Intolerance to ACE inhibitors, angiotensin receptor blockers, ARNi, or beta-blockers
Unexplained atrial arrhythmias, conduction system disease, or need for a pacemaker
History of musculoskeletal syndromes or procedures: CTS; lumbar spinal stenosis; spontaneous distal bicep tendon rupture; or shoulder, knee, or hip surgery

ACE angiotensin-converting enzyme, ARNi angiotensin receptor-neprilysin inhibitors, ATTR amyloid transthyretin, CTS carpal tunnel syndrome, HFpEF heart failure with preserved ejection fraction