Table 4.
Antimicrobial treatment of bacteraemic patients (n = 77)
| Antimicrobial agent | Initial agent (n = 76) | 2nd agent (n = 70) | 3rd agent (n = 45) | 4th agent (n = 21) | 5th agent (n = 6) |
|---|---|---|---|---|---|
| Cefuroxime | 66 (86.8%) | 1 (1.4%) | 5 (11.1%) | - | 1 (16.7%) |
| Cefuroxime + other agenta | 3 (3.9%) | 5 (7.1%) | 1 (2.2%) | 1 (4.8%) | - |
| Ceftriaxone | 2 (2.6%) | 4 (5.7%) | 4 (8.9%) | 4 (14.3%)b | - |
| Cefalexin | - | 3 (4.3%) | 1 (2.2%)c | 1 (4.8%) | - |
| Penicillins | 2 (2.6%) | 34 (48.6%) | 22 (48.9%) | 9 (42.9%) | 3 (50%) |
| Benzylpenicillin | - | 11 (15.7%) | 4 (8.9%) | 4 (19.0%)d | - |
| Phenoxymethylpenicillin | - | - | 4 (8.9%) | 1 (4.8%) | 2 (33.3%)d |
| Ampicillin | - | 7 (10.0%)d | 1 (2.2%) | - | - |
| Amoxicillin | 1 (1.3%) | 7 (10.0%) | 12 (26.7%)c | 2 (9.5%) | 1 (16.7%) |
| Amoxicillin with clavulanic acid | - | 5 (7.1%) | 1 (2.2%) | 2 (9.5%) | - |
| Cloxacillin | 1 (1.3%) | 4 (5.7%)e | - | - | |
| Broad-spectrumf | 4 (5.3%) | 11 (15.7%) | 5 (11.1%)d | 2 (9.5%) | 2 (33.3%) |
| Otherg | 1 (1.3%) | 12 (17.1%) | 7 (15.6%)h | 4 (19.0%) | - |
aOther agent = clindamycin, metronidazole, tobramycin, moxifloxacin, and vancomycin
bThree cases combined with (1) clindamycin (2) piperacillin-tazobactam and (3) linezolid
cOne case combined with metronidazole
dOne case combined with levofloxacin
eOne case combined with vancomycin
fImipenem, meropenem, and piperacillin-tazobactam
gCiprofloxacin, clindamycin, gentamicin, levofloxacin, nitrofurantoin, sulfa-trimethoprim, and vancomycin
hIn one case levofloxacin combined with vancomycin