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. 2022 Apr 22;12:6654. doi: 10.1038/s41598-022-10548-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of the fecal (A) fungal mycobiota and (B) bacterial microbiota composition before start of infliximab (IFX) therapy (baseline), two weeks and six weeks after treatment stratified by response to induction therapy to IFX. The plots present the most abundant genera, which are color-coded and shown on the right-side panel. (C) The standardized confounder-adjusted relative abundance of the fungal genera that significantly differed between response groups presented throughout the study and (D) the relative abundance of the bacterial genera and (E) classes that differed significantly at baseline between response groups presented throughout the study. R presents responders and NR presents non-responders. (*p FDR).