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. 2022 Apr 22;12:6625. doi: 10.1038/s41598-022-10554-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed lncRNAs in hippocampal tissues from mice in each group. (A) The number of upregulated (22) and downregulated (24) lncRNAs between ADNS and WT are shown. (B) The number of upregulated (29) and downregulated (39) differentially expressed lncRNAs between ADF and ADNS are shown. (C) Venn showed 5 lncRNAs at the intersection of ADNS versus ADF and WT versus ADNS. (D) KEGG analysis involving the top 20 terms of differentially expressed lncRNA co-located with mRNA in WT versus ADNS. Most genes focus in PI3K-AKT signal pathway. (E) KEGG analysis involving the top 20 terms of differentially expressed lncRNA co-located with mRNA in ADNS versus ADF. Most genes focus in cytokine-cytokine receptor interaction and cGMP-PKG signaling pathway. (F) KEGG analysis of differentially expressed lncRNA co-expressed with mRNA in WT versus ADNS. Most genes focus on the pathway of PI3K-Akt, MAPK, regulation of actin cytoskeleton and Rap1 signaling pathway. (G) KEGG analysis of differentially expressed lncRNA co-expressed with mRNA in ADNS versus ADF. Most genes focus on the pathway of phagosome, synaptic vesicle cycle and adipocytokine signaling pathway (KEGG pathways: https://www.kegg.jp/kegg/kegg1.html).