Table 1.
Pathology scores of isolated brain sections.
| Vaccine | NHP number | Frontal cortex | Corpus striatum | Thalamus | Mesencephalon | Cerebellum | Pons | Medulla oblongata | Meningitis | Total score |
|---|---|---|---|---|---|---|---|---|---|---|
| Empty vector | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
| Empty vector | 8 | 2 | 2 | 2 | 2 | 0 | 2 | 0 | 1 | 11 |
| Empty vector | 11 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 4 |
| Empty vector | 13 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 3 |
| Empty vector | 15 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 4 |
| Empty vector | 17 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 3 |
| Empty vector | Total Score | 5 | 7 | 7 | 3 | 0 | 2 | 0 | 3 | 27 |
| IM-DSJI | 5 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 1 | 6 |
| IM-DSJI | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| IM-DSJI | 9 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
| IM-DSJI | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| IM-DSJI | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| IM-DSJI | 18 | 3 | 3 | 3 | 3 | 0 | 3 | 3 | 2 | 20 |
| IM-DSJI | Total Score | 4 | 6 | 6 | 3 | 0 | 3 | 3 | 3 | 28 |
| ID-DSJI | 1 | 2 | 2 | 1 | 2 | 0 | 2 | 2 | 2 | 13 |
| ID-DSJI | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ID-DSJI | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 |
| ID-DSJI | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ID-DSJI | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ID-DSJI | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| ID-DSJI | Total Score | 2 | 3 | 1 | 2 | 0 | 2 | 2 | 2 | 15 |
| All Animals | Total Score | 11 | 16 | 14 | 8 | 0 | 7 | 5 | 9 | 70 |
Pathology score based on percentage of tissue affected by the histologic changes 0-negative, 1-minimal, >0–10%, 2-mild, >10–25%, 3-moderate, >25–50%, and 4-marked, >50–75%.
NHP Nonhuman primate.