Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 22;13(4):397. doi: 10.1038/s41419-022-04854-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — The expression levels and prognosis of Ago2 and TP63 in human cancers. A The proliferative capability of Ago2- knockdown was tested through colony assays in Saos2 cells. Colony numbers were counted. B, C The proliferative capabilities of H1299 (B) and SCC9 cells (C) transfected with p63 shRNA or Ago2 shRNA alone or together were tested through colony assays as indicated. D The proliferative capability of H1299 cells transfected with TAp63, ΔNp63, or Ago2 alone or together with Ago2 was examined by colony assays. In addition, H1299 clones stably expressing Ago2-shRNA were transfected with plasmids expressing TAp63 or ΔNp63 as indicated. Colony numbers were countered and plotted. All experiments were performed in triplicate. *P < 0.05, **P < 0.01, ***P < 0.001. E, F. Kaplan–Meier survival curves revealed that patients with high levels of TP63 and Ago2 had a significantly lower overall survival in human pancreatic ductal adenocarcinoma (www.kmplot.com). G, H Kaplan–Meier survival curves generated from www.kmplot.com revealed that patients with high levels of TP63 and Ago2 had significantly better overall survival in human lung adenocarcinoma.