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. 2022 Apr 22;13:2206. doi: 10.1038/s41467-022-29905-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Gene ontology analysis revealed ubiquinol synthesis pathway enrichment in KEAP1 mutant LUAD tumors. b Western blot analysis of KEAP1, NRF2, DHODH, and FSP1 protein levels in H1299 KEAP1 KO and H23 KEAP1 KO cells. c Western blot analysis of KEAP1, NRF2, and FSP1 protein levels in H1299 KEAP1 FSP1 DKO cells. d, e Cell death analysis of H1299 KEAP1 FSP1 DKO cells treated with RSL3 (d) and ML162 (e). f, g Cell death analysis of cotreatment of RSL3 (f) or ML162 (g) with iFSP1 in H1299 KEAP1 KO cells. h Ubiquinone/ubiquinol (CoQ/CoQH₂) ratio in H1299 KEAP1 FSP1 DKO cells. i–l Cell death analysis of H1299 KEAP1 KO cells (i, j) and H23 KEAP1 KO cells (k, l) cotreated with RSL3 + 4-CBA or ML162 + 4-CBA. Data were presented as (if mentioned otherwise) mean ± SD; n = 3. P value was determined by two-way ANOVA; ns not significant. Source data are provided as a Source Data file.