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. 2022 Apr 22;13:2206. doi: 10.1038/s41467-022-29905-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Clonogenic survival curves of the indicated H1299 cells exposed to X-ray irradiation at indicated doses following pretreatment with the indicated doses of 4-CBA or DMSO for 24 h. b Lipid peroxidation levels in the indicated H1299 cells at 24 h after exposure to 6 Gy X-ray irradiation following pretreatment with 4-CBA or DMSO for 24 h. c Clonogenic survival curves of A549 and H460 cells exposed to X-ray irradiation at indicated doses following pretreatment with the indicated doses of 4-CBA or DMSO for 24 h. d Lipid peroxidation levels in A549 and H460 cells at 24 h after exposure to 6 Gy X-ray irradiation following pretreatment with 4-CBA or DMSO for 24 h. e Protein levels of COQ₂ in A549 and H460 COQ₂ KO cells. f Clonogenic survival curve of the indicated A549 and H460 cells exposed to X-ray irradiation at indicated doses. g Lipid peroxidation levels in the indicated A549 or H460 cells at 24 h after exposure to 6 Gy X-ray irradiation. h Clonogenic survival curves of HBECs cells exposed to X-ray irradiation at indicated doses following pretreatment with the indicated doses of 4-CBA or DMSO for 24 h. i Lipid peroxidation levels in HBECs cells at 24 h after exposure to 6 Gy X-ray irradiation following pretreatment with 4-CBA or DMSO for 24 h. j Tumor volumes of A549 xenografts with indicated treatments at different time points (days) following exposure to 10 Gy of X-ray irradiation. Error bars are means ± SD, n = 7 or 8 tumors. k Tumor weights of A549 xenografts in the indicated treatment groups. Error bars are means ± SD, n = 7 or 8 tumors. l, m Representative images (l; scale bars, 20 μm) and scores (m) of IHC staining for 4-HNE in A549 xenograft tumors with indicated treatments. Error bars are means ± SD, n = 6 randomly selected magnification fields. n Tumor volumes of PDX TC494 in the indicated treatment groups at different time points (days) following exposure to 10 Gy of X-ray irradiation. Error bars are means ± SD, n = 5 or 6 tumors. o Tumor weights of PDX TC494 in the indicated treatment groups. Error bars are means ± SD, n = 5 or 6 tumors. p, q Representative images (p; scale bars, 20 μm) and scores (q) of IHC staining for 4-HNE in PDX TC494 tumors with indicated treatments. Error bars are means ± SD, n = 6 randomly selected magnification fields. Data were presented as (if mentioned otherwise) mean ± SD; n = 3. P value was determined by a two-tailed unpaired Student’s t-test; ns not significant. Source data are provided as a Source Data file.