Table 1.
Key resources table.
| Reagent or resource | Source | Identifier |
|---|---|---|
| Antibodies | ||
| KEAP1 | Santa Cruz Biotechnology | Cat# sc-365626 |
| Vinculin | Sigma | Cat# V4505 |
| SLC7A11 | Cell Signaling Technology | Cat# 12691 S |
| GPX4 | R&D Systems | Cat# MAB5457 |
| FSP1 | Proteintech | Cat# 20886-1-AP |
| NRF2 | Cell Signaling Technology | Cat# 12721 S |
| COQ2 | Santa Cruz Biotechnology | Cat# sc-517107 |
| DHODH | Proteintech | Cat# 14877-1-AP |
| anti-Ki-67 (D2H10) | Cell Signaling Technology | Cat# 9027 |
| anti-4-HNE | Abcam | Cat# ab46545 |
| anti-Phospho-Histone H2A.X (Ser139) | EMD Millipore | Cat# 05–636 |
| anti-Cleaved Caspase-3 | Cell Signaling Technology | Cat# 9661 |
| Biological Samples | ||
| PDX TC494 | University of Texas MD Anderson Cancer Center | N/A |
| Chemicals, Peptides, and Recombinant Proteins | ||
| RSL3 | Cayman Chemical | Cat# 19288 |
| ML162 | Cayman Chemical | Cat# 20455 |
| FIN56 | Selleck | Cat# S8254 |
| 4-CBA (4-chlorobenzoic acid) | Sigma | Cat# 135585 |
| iFSP1 | Cayman Chemical | Cat# 29483 |
| TBHQ | Selleck | Cat# S4990 |
| Apigenin | Cayman | Cat# 10010275 |
| SFN | Selleck | Cat# S5771 |
| Corn oil | Sigma | Cat# 8001-30-7 |
| Erastin | Selleck | Cat# S7247 |
| Ferrostatin | Sigma | Cat# SML0583 |
| BODIPYTM 581/591 C11 | ThermoFischer | Cat# D3861 |
| Propidium Iodide | Roche | Cat# 11348639001 |
| RPMI-1640 | Sigma | Cat# R8758 |
| Penicillin-Streptomycin | Life Technologies | Cat# 15140-122 |
| DMEM | Sigma | Cat# D6429 |
| DPBS | Sigma | Cat# D8537 |
| Critical Commercial Assays | ||
| cDNA Reverse Transcription Kit | Applied Biosystems | Cat# 43-688-14 |
| QuantiTect SYBR Green PCR Kit | Qiagen | Cat# 204143 |
| TaqMan™ Universal PCR Master Mix | Applied Biosystems | Cat# 4305719 |
| CCK8 | Dojindo | Cat# CK0413 |
| Experimental Models: Cell Lines | ||
| H1299 | Laboratory of Bingliang Fang | N/A |
| H23 | Laboratory of Bingliang Fang | N/A |
| H1703 | Laboratory of Bingliang Fang | N/A |
| H2126 | ATCC | Cat# CRL-5925 |
| H460 | Laboratory of Bingliang Fang | N/A |
| A549 | ATCC | Cat# CRL-7909 |
| HEK-293T | ATCC | CRL-11268 |
| Experimental Models: Organisms/Strains | ||
| Mouse: athymic nude mice (female, 4-6 weeks old) | Experimental Radiation Oncology Breeding Core Facility at MD Anderson Cancer Center | N/A |
| Mouse: NOD SCID Gamma (NSG) mice (female, 4-6 weeks old) | Experimental Radiation Oncology Breeding Core Facility at MD Anderson Cancer Center | N/A |
| Software and Algorithms | ||
| GraphPad | GraphPad | GraphPad |
| Cancer Dependency Map Portal | Cancer Dependency Map Portal | Cancer Dependency Map Portal |
| FlowJo | FlowJo | FlowJo |
| BD Accuri C6 Plus | BD Accuri C6 Plus | BD Accuri C6 Plus |
| UCSC Xena | UCSC Xena | UCSC Xena |